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HYOU1 Antibody (C-term) Blocking PeptideSynthetic peptide
| Country | United States
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| Catalog # | Size | Availability | Price | |
| BP7318b | 0.1 mg 400 ul | In Stock | $ 45.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
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HYOU1 Antibody (C-term) Blocking Peptide - Product info | |
| Primary Accession | Q9Y4L1 |
| Calculated MW | 111335 Da |
HYOU1 Antibody (C-term) Blocking Peptide - Additional info | |
| Gene ID 10525 | |
| Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. | |
| Precautions This product is for research use only. Not for use in diagnostic or therapeutic procedures. | |
HYOU1 Antibody (C-term) Blocking Peptide - Protein Information | |
| Name HYOU1 | |
| Synonyms GRP170, ORP150 | |
| Function Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding | |
| Cellular Location Endoplasmic reticulum lumen. | |
| Tissue Location Highly expressed in tissues that contain well- developed endoplasmic reticulum and synthesize large amounts of secretory proteins. Highly expressed in liver and pancreas and lower expression in brain and kidney. Also expressed in macrophages within aortic atherosclerotic plaques, and in breast cancers | |
HYOU1 Antibody (C-term) Blocking Peptide - Related products
AP7318b: HYOU1 Antibody (C-term)
AP7318c: HYOU1 Antibody (Center)
RI12622: HYOU1 predesign siRNA
LY11627a: HYOU1 Over-expression Lysate
BP7318b: HYOU1 Antibody (C-term) Blocking Peptide
HYOU1 Antibody (C-term) Blocking Peptide - Research Areas
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BACKGROUND
HYOU1 belongs to the heat shock protein 70 family. The protein is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness. This signal peptide-lacking protein, which is only 3 amino acids shorter than the mature protein in the ER, is thought to have a housekeeping function in the cytosol. In rat, this protein localizes to both the ER by a carboxy-terminal peptide sequence and to mitochondria by an amino-terminal targeting signal.
REFERENCES
Kitao,Y., Matsuyama,T. Antioxid. Redox Signal. 9 (5), 589-595 (2007)Bando,Y., Ogawa,S. Am. J. Physiol., Cell Physiol. 278 (6), C1172-C1182 (2000)
