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MFAP5 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q13361 |
|---|---|
| Clone Names | 80902024 |
| Gene ID | 8076 |
|---|---|
| Other Names | Microfibrillar-associated protein 5, MFAP-5, MP25, Microfibril-associated glycoprotein 2, MAGP-2, MFAP5, MAGP2 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP7319b was selected from the C-term region of human MFAP5. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | MFAP5 |
|---|---|
| Synonyms | MAGP2 |
| Function | May play a role in hematopoiesis. In the cardiovascular system, could regulate growth factors or participate in cell signaling in maintaining large vessel integrity (By similarity). Component of the elastin-associated microfibrils (PubMed:8557636). |
| Cellular Location | Secreted, extracellular space, extracellular matrix |
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Provided below are standard protocols that you may find useful for product applications.
Background
MFAP5 is a 25-kD microfibril-associated glycoprotein which is rich in serine and threonine residues. The protein lacks a hydrophobic carboxyl terminus and proline-, glutamine-, and tyrosine-rich regions, which are characteristics of a related 31-kDa microfibril-associated glycoprotein (MFAP2). The close similarity between these two proteins is confined to a central region of 60 aa where precise alignment of 7 cysteine residues occurs. The structural differences suggest that this protein has some functions that are distinct from those of MFAP2.
References
Albig,A.R., Becenti,D.J. Microvasc. Res. 76 (1), 7-14 (2008)Miyamoto,A., Lau,R. J. Biol. Chem. 281 (15), 10089-10097 (2006)Penner,A.S., Rock,M.J. J. Biol. Chem. 277 (38), 35044-35049 (2002)Hatzinikolas,G. J. Biol. Chem. 273 (45), 29309-29314 (1998)
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