|Other Names||Complement C1q subcomponent subunit A, C1QA|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7324b was selected from the C-term region of human C1QA. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.|
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Provided below are standard protocols that you may find useful for product applications.
C1QA is a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on hromosome 1.
Dardiotis,E., Koutsou,P. J. Neurol. Sci. (2009) In pressMartens,H.A., Zuurman,M.W. Ann. Rheum. Dis. 68 (5), 715-720 (2009)Racila,E., Link,B.K. Clin. Cancer Res. 14 (20), 6697-6703 (2008)Sjoberg,A.P., Nystrom,S. Mol. Immunol. 45 (11), 3213-3221 (2008)
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