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> home > Products > Peptides > Biological Process > Organ Development > PCSK9 Antibody (N-term) Blocking Peptide
PCSK9 Antibody (N-term) Blocking PeptideSynthetic peptide
| Country | United States
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| Catalog # | Size | Availability | Price | |
| BP7333a | 0.1 mg 400 ul | In Stock | $ 45.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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PCSK9 Antibody (N-term) Blocking Peptide - Product info | |
| Primary Accession | Q8NBP7 |
| Clone Names | 80703099 |
| Calculated MW | 74286 Da |
PCSK9 Antibody (N-term) Blocking Peptide - Additional info | |
| Gene ID 255738 | |
| Target/Specificity The synthetic peptide sequence used to generate the antibody AP7333a was selected from the N-term region of human PCSK9. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. | |
| Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. | |
| Precautions This product is for research use only. Not for use in diagnostic or therapeutic procedures. | |
PCSK9 Antibody (N-term) Blocking Peptide - Protein Information | |
| Name PCSK9 | |
| Synonyms NARC1 | |
| Function Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. Can induce ubiquitination of LDLR leading to its subsequent degradation Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway. Inhibits epithelial Na(+) channel (ENaC)-mediated Na(+) absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation Regulates neuronal apoptosis via modulation of LRP8/APOER2 levels and related anti-apoptotic signaling pathways | |
| Cellular Location Cytoplasm. Secreted. Endosome. Lysosome. Cell surface. Endoplasmic reticulum. Golgi apparatus Note=Autocatalytic cleavage is required to transport it from the endoplasmic reticulum to the Golgi apparatus and for the secretion of the mature protein. Localizes to the endoplasmic reticulum in the absence of LDLR and co-localizes to the cell surface and to the endosomes/lysosomes in the presence of LDLR. The sorting to the cell surface and endosomes is required in order to fully promote LDLR degradation | |
| Tissue Location Expressed in neuro-epithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells | |
PCSK9 Antibody (N-term) Blocking Peptide - Related products
AP7333a: PCSK9 Antibody (N-term)
AP7333b: PCSK9 Antibody (C-term)
RI13860: PCSK9 predesign siRNA
BP7333a: PCSK9 Antibody (N-term) Blocking Peptide
PCSK9 Antibody (N-term) Blocking Peptide - Research Areas
PeptidesBiological ProcessOrgan DevelopmentMetabolic ProcessPrimary Metabolic ProcessProtein Metabolic ProcessCellular Protein Metabolic ProcessCellular Metabolic ProcessCellular ProcessPositive Regulation Of Biological ProcessPositive Regulation Of Cellular ProcessRegulation Of Cell DeathRegulation Of Programmed Cell DeathResponse To Organic SubstanceRegulation Of ApoptosisPositive Regulation Of Cellular Metabolic ProcessPositive Regulation Of Metabolic ProcessPositive Regulation Of Macromolecule Metabolic ProcessLipid Metabolic ProcessNegative Regulation Of Cellular ProcessNegative Regulation Of Biological ProcessResponse To Chemical StimulusResponse To Endogenous StimulusSystem DevelopmentMacromolecule Metabolic ProcessMulticellular Organismal DevelopmentAnatomical Structure DevelopmentResponse To Hormone StimulusRegulation Of Protein Metabolic ProcessRegulation Of Cellular Protein Metabolic ProcessDevelopmental Process
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BACKGROUND
PCSK9 is a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. This protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. The protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons.
REFERENCES
Abifadel,M., Rabes,J.P. Hum. Mutat. 30 (7), E682-E691 (2009)McNutt,M.C., Kwon,H.J. J. Biol. Chem. 284 (16), 10561-10570 (2009)Shioji,K., Mannami,T. J. Hum. Genet. 49 (2), 109-114 (2004)Abifadel,M., Varret,M. Nat. Genet. 34 (2), 154-156 (2003)
