|Other Names||Pituitary homeobox 1, Hindlimb-expressed homeobox protein backfoot, Homeobox protein PITX1, Paired-like homeodomain transcription factor 1, PITX1, BFT, PTX1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7334c was selected from the Center region of human PITX1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Sequence-specific transcription factor that binds gene promoters and activates their transcription. May play a role in the development of anterior structures, and in particular, the brain and facies and in specifying the identity or structure of hindlimb.|
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Provided below are standard protocols that you may find useful for product applications.
PITX1 is a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family are involved in organ development and left-right asymmetry. This protein acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin.
Grimminger,P., Ling,F.C. Anticancer Res. 29 (4), 1281-1286 (2009)Gurnett,C.A., Alaee,F. Am. J. Hum. Genet. 83 (5), 616-622 (2008)Philippi,A., Tores,F. BMC Med. Genet. 8, 74 (2007)Shang,J., Li,X. Genomics 40 (1), 108-113 (1997)
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