|Other Names||Poly(U)-specific endoribonuclease, 31--, Placental protein 11, PP11, Protein endoU, Uridylate-specific endoribonuclease, ENDOU|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7335b was selected from the C-term region of human PP11. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Endoribonuclease that cleaves single-stranded RNAs at uridylates and releases products that have 2'-3'-cyclic phosphate termini.|
|Tissue Location||Placental-specific, but also associated with various malignant neoplasms|
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Provided below are standard protocols that you may find useful for product applications.
PP11 is a protein with protease activity. Its specific function has not been determined. The protein may be useful as a tumor marker.
Laneve,P., Gioia,U. J. Biol. Chem. 283 (50), 34712-34719 (2008)Jenne,D. Biochem. Biophys. Res. Commun. 176 (3), 1000-1006 (1991)Grundmann,U., Romisch,J. DNA Cell Biol. 9 (4), 243-250 (1990)Inaba,N., Ishige,H. Oncodev. Biol. Med. 3 (5-6), 379-389 (1982)
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