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PTHLH Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P12272
Clone Names 80703040
Peptide ID 80703040
Additional Information
Gene ID 5744
Other Names Parathyroid hormone-related protein, PTH-rP, PTHrP, Parathyroid hormone-like protein, PLP, PTHrP[1-36], PTHrP[38-94], Osteostatin, PTHrP[107-139], PTHLH, PTHRP
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7336c was selected from the Center region of human PTHLH. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PTHLH
Synonyms PTHRP
Function Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity). Promotes colon cancer cell migration and invasion in an integrin alpha-6/beta-1- dependent manner through activation of Rac1.
Cellular Location Cytoplasm. Nucleus. Secreted.
Tissue Location Ubiquitous. Also expressed in the mammary gland
Research Areas
Citations (0)

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Background

PTHLH is a member of the parathyroid hormone family. This hormone regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. This hormone is involved in lactation possibly by regulating the mobilization and transfer of calcium to the milk. The receptor of this hormone, PTHR1, is responsible for most cases of humoral hypercalcemia of malignancy.

References

Trynka,G., Zhernakova,A. Gut 58 (8), 1078-1083 (2009)Nakao,A., Kajiya,H. J. Dent. Res. 88 (6), 551-556 (2009)Iwamura,M., Hellman,J. Urology 48 (2), 317-325 (1996)Fenton,A.J., Kemp,B.E. Endocrinology 129 (6), 3424-3426 (1991)

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$ 80.00
Cat# BP7336c
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