CPA4 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9UI42 |
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Clone Names | 80410128 |
Gene ID | 51200 |
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Other Names | Carboxypeptidase A4, 3417-, Carboxypeptidase A3, CPA4, CPA3 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP7338b was selected from the C-term region of human CPA4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | CPA4 |
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Synonyms | CPA3 |
Function | Metalloprotease that could be involved in the histone hyperacetylation pathway (PubMed:10383164). Releases a C-terminal amino acid, with preference for -Phe, -Leu, -Ile, -Met, -Tyr and -Val (PubMed:20385563). |
Cellular Location | Secreted. |
Tissue Location | Fetal expression in the adrenal gland, brain, heart, intestine, kidney, liver and lung. Except for fetal brain that shows no imprinting, expression was found preferentially from the maternal allele |
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Provided below are standard protocols that you may find useful for product applications.
Background
CPA4 is a member of the carboxypeptidase A/B subfamily. Carboxypeptidases are zinc-containing exopeptidases that catalyze the release of carboxy-terminal amino acids, and are synthesized as zymogens that are activated by proteolytic cleavage. This protein could be involved in the histone hyperacetylation pathway. It is imprinted and may be a strong candidate protein for prostate cancer aggressiveness.
References
Ross,P.L., Cheng,I. BMC Cancer 9, 69 (2009)Bentley,L., Nakabayashi,K. J. Med. Genet. 40 (4), 249-256 (2003)Kayashima,T., Yamasaki,K. Hum. Genet. 112 (3), 220-226 (2003)Hayashida,S., Yamasaki,K. Genomics 66 (2), 221-225 (2000)
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