|Other Names||Clarin-1, Usher syndrome type-3 protein, CLRN1, USH3A|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7339b was selected from the C-term region of human CLRN1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May have a role in the excitatory ribbon synapse junctions between hair cells and cochlear ganglion cells and presumably also in analogous synapses within the retina.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Widely expressed. Found in the retina.|
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Provided below are standard protocols that you may find useful for product applications.
CLRN1 is a protein that contains a cytosolic N-terminus, multiple helical transmembrane domains, and an endoplasmic reticulum membrane retention signal, TKGH, in the C-terminus. The protein may be important in development and homeostasis of the inner ear and retina.
Herrera,W., Aleman,T.S. Invest. Ophthalmol. Vis. Sci. 49 (6), 2651-2660 (2008)Aller,E., Jaijo,T. Clin. Genet. 66 (6), 525-529 (2004)Joensuu,T., Hamalainen,R. Genomics 63 (3), 409-416 (2000)
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