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CLRN1 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P58418 |
|---|---|
| Clone Names | 80722032 |
| Gene ID | 7401 |
|---|---|
| Other Names | Clarin-1, Usher syndrome type-3 protein, CLRN1, USH3A |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP7339b was selected from the C-term region of human CLRN1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CLRN1 |
|---|---|
| Synonyms | USH3A |
| Function | May have a role in the excitatory ribbon synapse junctions between hair cells and cochlear ganglion cells and presumably also in analogous synapses within the retina. |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Widely expressed. Found in the retina. |
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Provided below are standard protocols that you may find useful for product applications.
Background
CLRN1 is a protein that contains a cytosolic N-terminus, multiple helical transmembrane domains, and an endoplasmic reticulum membrane retention signal, TKGH, in the C-terminus. The protein may be important in development and homeostasis of the inner ear and retina.
References
Herrera,W., Aleman,T.S. Invest. Ophthalmol. Vis. Sci. 49 (6), 2651-2660 (2008)Aller,E., Jaijo,T. Clin. Genet. 66 (6), 525-529 (2004)Joensuu,T., Hamalainen,R. Genomics 63 (3), 409-416 (2000)
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