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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   MYO1A Antibody (Center S291) Blocking Peptide   

MYO1A Antibody (Center S291) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9UBC5
Clone Names 80703091
Peptide ID 80703091
Additional Information
Gene ID 4640
Other Names Unconventional myosin-Ia, Brush border myosin I, BBM-I, BBMI, Myosin I heavy chain, MIHC, MYO1A, MYHL
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7343c was selected from the Center region of human MYO1A. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MYO1A
Synonyms MYHL
Function Involved in directing the movement of organelles along actin filaments.
Research Areas
Citations (0)

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Background

MYO1A belongs to the myosin superfamily. Myosins are molecular motors that, upon interaction with actin filaments, utilize energy from ATP hydrolysis to generate mechanical force. Each myosin has a conserved N-terminal motor domain that contains both ATP-binding and actin-binding sequences. Following the motor domain is a light-chain-binding 'neck' region containing 1-6 copies of a repeat element, the IQ motif, that serves as a binding site for calmodulin or other members of the EF-hand superfamily of calcium-binding proteins. At the C-terminus, each myosin class has a distinct tail domain that serves in dimerization, membrane binding, protein binding, and/or enzymatic activities and targets each myosin to its particular subcellular location. The kidney epithelial cell line, LLC-PK1-CL4 (CL4), forms a well ordered brush border (BB) on its apical surface. Experiments indicate that the brush border population of the protein turns over rapidly, while its head and tail domains interact transiently with the core actin and plasma membrane, respectively. A rapidly exchanging pool of the protein envelops an actin core bundle that, by comparison, is static in structure.

References

D'Adamo,P., Pinna,M. Hum. Genet. 112 (3), 319-320 (2003)Hoshimaru,M., Fujio,Y. J. Biochem. 106 (3), 455-459 (1989)Durrbach,A., Collins,K. Proc. Natl. Acad. Sci. U.S.A. 93 (14), 7053-7058 (1996)

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$ 80.00
Cat# BP7343c
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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