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S100A6 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P06703
Clone Names 80722094
Additional Information
Gene ID 6277
Other Names Protein S100-A6, Calcyclin, Growth factor-inducible protein 2A9, MLN 4, Prolactin receptor-associated protein, PRA, S100 calcium-binding protein A6, S100A6, CACY
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7346b was selected from the C-term region of human S100A6. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name S100A6
Synonyms CACY
Function May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative.
Cellular Location Nucleus envelope. Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side
Research Areas
Citations (0)
citation

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Background

S100A6 is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis.

References

van Dieck,J. J. Biol. Chem. 284 (20), 13804-13811 (2009)Tsoporis,J.N., Izhar,S. J. Biol. Chem. 283 (44), 30174-30183 (2008)Lee,Y.T., Dimitrova,Y.N. Biochemistry 47 (41), 10921-10932 (2008)Melle,C., Ernst,G. PLoS ONE 3 (12), E3767 (2008)

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$ 277.78
Cat# BP7346b
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