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BF Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P00751
Clone Names 80902070
Peptide ID 80902070
Additional Information
Gene ID 629
Other Names Complement factor B, C3/C5 convertase, Glycine-rich beta glycoprotein, GBG, PBF2, Properdin factor B, Complement factor B Ba fragment, Complement factor B Bb fragment, CFB, BF, BFD
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7357c was selected from the Center region of human BF. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CFB
Synonyms BF, BFD
Function Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B- lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes.
Cellular Location Secreted.
Research Areas
Citations (0)

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BF is complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation.


Baatz,H., Klin Monatsbl Augenheilkd 226 (8), 654-658 (2009)Goring,K., Am. J. Physiol., Cell Physiol. 296 (5), C1140-C1150 (2009)

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$ 80.00
Cat# BP7357c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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