|Other Names||Apolipoprotein L1, Apolipoprotein L, Apo-L, ApoL, Apolipoprotein L-I, ApoL-I, APOL1, APOL|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7361a was selected from the region of human APOL1-BH3 Domain. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver.|
|Tissue Location||Plasma. Found on APOA-I-containing high density lipoprotein (HDL3). Expressed in pancreas, lung, prostate, liver, placenta and spleen|
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Provided below are standard protocols that you may find useful for product applications.
APOL1 is a secreted high density lipoprotein which binds to apolipoprotein A-I. Apolipoprotein A-I is a relatively abundant plasma protein and is the major apoprotein of HDL. It is involved in the formation of most cholesteryl esters in plasma and also promotes efflux of cholesterol from cells. This apolipoprotein L family member may play a role in lipid exchange and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver.
Li,Q., Clin. Chim. Acta 403 (1-2), 152-155 (2009)Zhaorigetu,S., Autophagy 4 (8), 1079-1082 (2008)
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