|Other Names||Cathepsin B, APP secretase, APPS, Cathepsin B1, Cathepsin B light chain, Cathepsin B heavy chain, CTSB, CPSB|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7367c was selected from the Center region of human CATB. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.|
|Cellular Location||Lysosome. Melanosome. Secreted, extracellular space. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV|
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Provided below are standard protocols that you may find useful for product applications.
The protein CATB is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer disease, the most common cause of dementia. Overexpression of the protein, which is a member of the peptidase C1 family, has been associated with esophageal adenocarcinoma and other tumors.
Zhang,H., J. Immunol. 182 (11), 6993-7000 (2009)Duncan,J.A., J. Immunol. 182 (10), 6460-6469 (2009)
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