|Other Names||Collagen alpha-1(IV) chain, Arresten, COL4A1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7369a was selected from the N-term region of human COL4A1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.|
|Cellular Location||Secreted, extracellular space, extracellular matrix, basement membrane|
|Tissue Location||Highly expressed in placenta.|
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Provided below are standard protocols that you may find useful for product applications.
COL4A1 is the major type IV alpha collagen chain of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter.
de Vries,L.S., Ann. Neurol. 65 (1), 12-18 (2009)Mazouni,C., Br. J. Cancer 99 (1), 68-71 (2008)
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