|Other Names||Calponin-2, Calponin H2, smooth muscle, Neutral calponin, CNN2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7373a was selected from the N-term region of human Calponin-2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.|
|Tissue Location||Heart and smooth muscle.|
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Provided below are standard protocols that you may find useful for product applications.
Calponin-2, which can bind actin, calmodulin, troponin C, and tropomyosin, may function in the structural organization of actin filaments. The protein could play a role in smooth muscle contraction and cell adhesion.
Hossain,M.M., Am. J. Physiol., Cell Physiol. 284 (1), C156-C167 (2003)Fukui,Y., J. Dermatol. Sci. 14 (1), 29-36 (1997)
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