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Calponin-2 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q99439 |
|---|---|
| Clone Names | 80808070 |
| Gene ID | 1265 |
|---|---|
| Other Names | Calponin-2, Calponin H2, smooth muscle, Neutral calponin, CNN2 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP7373c was selected from the Center region of human Calponin-2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CNN2 |
|---|---|
| Function | Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. |
| Tissue Location | Heart and smooth muscle. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Calponin-2, which can bind actin, calmodulin, troponin C, and tropomyosin, may function in the structural organization of actin filaments. The protein could play a role in smooth muscle contraction and cell adhesion.
References
Hossain,M.M., Am. J. Physiol., Cell Physiol. 284 (1), C156-C167 (2003)Fukui,Y., J. Dermatol. Sci. 14 (1), 29-36 (1997)
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