|Other Names||Calponin-2, Calponin H2, smooth muscle, Neutral calponin, CNN2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7373d was selected from the Center region of human CNN2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.|
|Tissue Location||Heart and smooth muscle.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Calponin-2, which can bind actin, calmodulin, troponin C, and tropomyosin, may function in the structural organization of actin filaments. The protein could play a role in smooth muscle contraction and cell adhesion.
Hossain,M.M., Am. J. Physiol., Cell Physiol. 284 (1), C156-C167 (2003)Fukui,Y., J. Dermatol. Sci. 14 (1), 29-36 (1997)
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