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PDZRN3 Antibody (Center E388) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9UPQ7 |
|---|---|
| Clone Names | 80917128 |
| Gene ID | 23024 |
|---|---|
| Other Names | E3 ubiquitin-protein ligase PDZRN3, 632-, Ligand of Numb protein X 3, PDZ domain-containing RING finger protein 3, Semaphorin cytoplasmic domain-associated protein 3, Protein SEMACAP3, PDZRN3, KIAA1095, LNX3, SEMCAP3 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP7375c was selected from the Center region of human PDZRN3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PDZRN3 |
|---|---|
| Synonyms | KIAA1095, LNX3, SEMCAP3 |
| Function | E3 ubiquitin-protein ligase. Plays an important role in regulating the surface level of MUSK on myotubes. Mediates the ubiquitination of MUSK, promoting its endocytosis and lysosomal degradation. Might contribute to terminal myogenic differentiation. |
| Cellular Location | Synapse {ECO:0000250|UniProtKB:Q69ZS0}. Cytoplasm {ECO:0000250|UniProtKB:E7FDW2}. Note=Localizes to the postsynaptic region of neuromuscular junctions. {ECO:0000250|UniProtKB:Q69ZS0} |
| Tissue Location | Widely expressed, including in the heart, skeletal muscle and liver and, at lower levels, in the brain, colon, small intestine, placenta and lung. Down-regulated in ovarian serous papillary tumors. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
References
Meyer,G., Neuropharmacology 47 (5), 724-733 (2004)Katoh,M., Int. J. Mol. Med. 13 (4), 607-613 (2004)
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