|Other Names||E3 ubiquitin-protein ligase PDZRN3, 632-, Ligand of Numb protein X 3, PDZ domain-containing RING finger protein 3, Semaphorin cytoplasmic domain-associated protein 3, Protein SEMACAP3, PDZRN3, KIAA1095, LNX3, SEMCAP3|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7375c was selected from the Center region of human PDZRN3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||KIAA1095, LNX3, SEMCAP3|
|Function||E3 ubiquitin-protein ligase. Plays an important role in regulating the surface level of MUSK on myotubes. Mediates the ubiquitination of MUSK, promoting its endocytosis and lysosomal degradation. Might contribute to terminal myogenic differentiation (By similarity).|
|Tissue Location||Widely expressed, including in the heart, skeletal muscle and liver and, at lower levels, in the brain, colon, small intestine, placenta and lung. Down-regulated in ovarian serous papillary tumors.|
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Provided below are standard protocols that you may find useful for product applications.
Meyer,G., Neuropharmacology 47 (5), 724-733 (2004)Katoh,M., Int. J. Mol. Med. 13 (4), 607-613 (2004)
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