|Other Names||Dihydrofolate reductase, DHFR|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7378c was selected from the Center region of human DHFR. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1.|
|Tissue Location||Widely expressed in fetal and adult tissues, including throughout the fetal and adult brains and whole blood Expression is higher in the adult brain than in the fetal brain|
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Provided below are standard protocols that you may find useful for product applications.
Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids.Dihydrofolate reductase deficiency has been linked to megaloblastic anemia.
Gemmati,D., Am. J. Hematol. 84 (8), 526-529 (2009)Stockman,B.J., Biochemistry 31 (1), 218-229 (1992)
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