|Other Names||Nuclease EXOG, mitochondrial, 3130-, Endonuclease G-like 1, Endo G-like 1, EXOG, ENDOGL1, ENDOGL2, ENGL|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7384a was selected from the N-term region of human ENDOGL1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||ENDOGL1, ENDOGL2, ENGL|
|Function||Endo/exonuclease with nicking activity towards supercoiled DNA, a preference for single-stranded DNA and 5'-3' exonuclease activity.|
|Cellular Location||Mitochondrion inner membrane|
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Provided below are standard protocols that you may find useful for product applications.
ENDOGL1 is an endo/exonuclease with 5'-3' exonuclease activity. The enzyme catalyzes the hydrolysis of ester linkages at the 5' end of a nucleic acid chain. This enzyme is localized to the mitochondria and may play a role in programmed cell death.
Cymerman,I.A., Nucleic Acids Res. 36 (4), 1369-1379 (2008)
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