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GMPR Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P36959 |
|---|---|
| Clone Names | 80513165 |
| Gene ID | 2766 |
|---|---|
| Other Names | GMP reductase 1, Guanosine 5'-monophosphate oxidoreductase 1, Guanosine monophosphate reductase 1, GMPR, GMPR1 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP7386a was selected from the N-term region of human GMPR. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | GMPR |
|---|---|
| Synonyms | GMPR1 {ECO:0000255|HAMAP-Rule:MF_03195} |
| Function | Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Guanosine monophosphate reductase (EC 1.7.1.7) catalyzes the irreversible NADPH-dependent reductive deamination of guanosine monophosphate (GMP) to inosine monophosphate (IMP). GMPR is able to convert guanosine nucleotides to the pivotal precursor of both guanine (G) and adenine (A) nucleotides. It plays an important role in maintaining the intracellular balance of A and G nucleotides.
References
Deng,Y., Int. J. Biochem. Cell Biol. 34 (9), 1035-1050 (2002)Salvatore,D., J. Biol. Chem. 273 (47), 31092-31096 (1998)
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