|Other Names||Gamma-glutamyltransferase 5, GGT 5, Gamma-glutamyl transpeptidase-related enzyme, GGT-rel, Gamma-glutamyltransferase-like activity 1, Gamma-glutamyltranspeptidase 5, Glutathione hydrolase 5, Leukotriene-C4 hydrolase, Gamma-glutamyltransferase 5 heavy chain, Gamma-glutamyltransferase 5 light chain, GGT5, GGTLA1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7392a was selected from the N-term region of human GGTLA1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4).|
|Cellular Location||Membrane; Single-pass type II membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
This gene is a member of gamma-glutamyl transpeptidase enzymes. This enzyme consists of a heavy and a light chain, and is able to hydrolyze the gamma-glutamyl moiety of glutathione. It converts leukotriene C4 to leukotriene D4, however, it doesn't convert synthetic substrates that are commonly used to assay gamma-glutamyl transpeptidase.
Heisterkamp,N., Hum. Genet. 123 (4), 321-332 (2008)Enoiu,M., Free Radic. Biol. Med. 29 (9), 825-833 (2000)
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