|Other Names||Prolyl 4-hydroxylase subunit alpha-2, 4-PH alpha-2, Procollagen-proline, 2-oxoglutarate-4-dioxygenase subunit alpha-2, P4HA2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7393a was selected from the N-term region of human P4HA2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.|
|Cellular Location||Endoplasmic reticulum lumen.|
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Provided below are standard protocols that you may find useful for product applications.
P4HA2 is a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains.
Koivunen,P., J. Biol. Chem. 281 (39), 28712-28720 (2006)Grimmer,C., Am. J. Pathol. 169 (2), 491-502 (2006)Kukkola,L., J. Biol. Chem. 278 (48), 47685-47693 (2003)
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