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P4HA2 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O15460 |
|---|---|
| Clone Names | 80917117 |
| Gene ID | 8974 |
|---|---|
| Other Names | Prolyl 4-hydroxylase subunit alpha-2, 4-PH alpha-2, Procollagen-proline, 2-oxoglutarate-4-dioxygenase subunit alpha-2, P4HA2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | P4HA2 |
|---|---|
| Function | Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. |
| Cellular Location | Endoplasmic reticulum lumen. |
| Tissue Location | Expressed in the heart, placenta, lung and pancreas. |
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Provided below are standard protocols that you may find useful for product applications.
Background
P4HA2 is a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains.
References
Koivunen,P., J. Biol. Chem. 281 (39), 28712-28720 (2006)Grimmer,C., Am. J. Pathol. 169 (2), 491-502 (2006)Kukkola,L., J. Biol. Chem. 278 (48), 47685-47693 (2003)
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