|Other Names||Putative RNA-binding protein 3, RNA-binding motif protein 3, RNPL, RBM3, RNPL|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7397c was selected from the Center region of human RBM3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Cold-inducible mRNA binding protein that enhances global protein synthesis at both physiological and mild hypothermic temperatures. Reduces the relative abundance of microRNAs, when overexpressed. Enhances phosphorylation of translation initiation factors and active polysome formation (By similarity).|
|Cellular Location||Nucleus. Cytoplasm. Cell projection, dendrite Note=Localizes in mRNA granules in dentrites.|
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Provided below are standard protocols that you may find useful for product applications.
RBM3 is a member of the glycine-rich RNA-binding protein family and a protein with one RNA recognition motif (RRM) domain. Expression of this protein is induced by cold shock and low oxygen tension.
Zeng,Y., J. Cell. Biochem. 107 (1), 179-188 (2009)Sureban,S.M., Oncogene 27 (33), 4544-4556 (2008)
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