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CALHM1/FAM26C Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8IU99 |
|---|---|
| Clone Names | 80722004 |
| Gene ID | 255022 |
|---|---|
| Other Names | Calcium homeostasis modulator protein 1, Protein FAM26C, CALHM1, FAM26C |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP7399c was selected from the Center region of human CALHM1/FAM26C. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CALHM1 (HGNC:23494) |
|---|---|
| Synonyms | FAM26C |
| Function | Pore-forming subunit of a voltage-gated ion channel required for sensory perception of sweet, bitter and umami tastes (By similarity). Specifically present in type II taste bud cells, where it plays a central role in sweet, bitter and umami taste perception by inducing ATP release from the cell, ATP acting as a neurotransmitter to activate afferent neural gustatory pathways (By similarity). Together with CALHM3, forms a fast-activating voltage-gated ATP-release channel in type II taste bud cells (TBCs) (By similarity). Acts both as a voltage-gated and calcium-activated ion channel: mediates neuronal excitability in response to changes in extracellular Ca(2+) concentration (PubMed:22711817, PubMed:23300080). Has poor ion selectivity and forms a wide pore (around 14 Angstroms) that mediates permeation of Ca(2+), Na(+) and K(+), as well as permeation of monovalent anions (PubMed:22711817). Acts as an activator of the ERK1 and ERK2 cascade (PubMed:23345406). Triggers endoplasmic reticulum stress by reducing the calcium content of the endoplasmic reticulum (PubMed:21574960). May indirectly control amyloid precursor protein (APP) proteolysis and aggregated amyloid-beta (Abeta) peptides levels in a Ca(2+) dependent manner (PubMed:18585350). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:D3Z291}. Note=Colocalizes with HSPA5 at the endoplasmic reticulum (PubMed:18585350). Localizes to the basolateral membrane of epithelial cells including taste cells (By similarity) {ECO:0000250|UniProtKB:D3Z291, ECO:0000269|PubMed:18585350} |
| Tissue Location | Predominantly expressed in adult brain. Detected also in retinoic acid-differentiated SH-SY5Y cells. Specifically expressed in circumvallate taste bud cells |
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Provided below are standard protocols that you may find useful for product applications.
Background
CALHM1 is a cerebral Ca(2+) channel that controls processing of amyloid-beta (A-beta) precursor protein.
References
Beecham,G.W., Ann. Hum. Genet. 73 (PT 3), 379-381 (2009)Sleegers,K., Hum. Mutat. 30 (4), E570-E574 (2009)Bertram,L., Cell 135 (6), 993-994 (2008)Dreses-Werringloer,U., Cell 133 (7), 1149-1161 (2008)
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