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CALHM1/FAM26C Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q8IU99
Clone Names 80722004
Peptide ID 80722004
Additional Information
Gene ID 255022
Other Names Calcium homeostasis modulator protein 1, Protein FAM26C, CALHM1, FAM26C
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7399c was selected from the Center region of human CALHM1/FAM26C. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms FAM26C
Function Pore-forming subunit of a voltage-gated ion channel required for sensory perception of sweet, bitter and umami tastes. Specifically present in type II taste bud cells, where it plays a central role in sweet, bitter and umami taste perception by inducing ATP release from the cell, ATP acting as a neurotransmitter to activate afferent neural gustatory pathways. Acts both as a voltage-gated and calcium-activated ion channel: mediates neuronal excitability in response to changes in extracellular Ca(2+) concentration. Has poor ion selectivity and forms a wide pore (around 14 Angstroms) that mediates permeation of Ca(2+), Na(+) and K(+), as well as permeation of monovalent anions. Acts as an activator of the ERK1 and ERK2 cascade. Triggers endoplasmic reticulum stress by reducing the calcium content of the endoplasmic reticulum. May indirectly control amyloid precursor protein (APP) proteolysis and aggregated amyloid-beta (Abeta) peptides levels in a Ca(2+) dependent manner.
Cellular Location Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein Note=Colocalizes with HSPA5 at the endoplasmic reticulum
Tissue Location Predominantly expressed in adult brain. Detected also in retinoic acid-differentiated SH-SY5Y cells Specifically expressed in circumvallate taste bud cells
Research Areas
Citations (0)

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CALHM1 is a cerebral Ca(2+) channel that controls processing of amyloid-beta (A-beta) precursor protein.


Beecham,G.W., Ann. Hum. Genet. 73 (PT 3), 379-381 (2009)Sleegers,K., Hum. Mutat. 30 (4), E570-E574 (2009)Bertram,L., Cell 135 (6), 993-994 (2008)Dreses-Werringloer,U., Cell 133 (7), 1149-1161 (2008)

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$ 80.00
Cat# BP7399c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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Ordering Information

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