|Other Names||Casein kinase I isoform epsilon, CKI-epsilon, CKIe, CSNK1E|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7403a was selected from the C-term region of human CK1e . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine- induced granuloytic differentiation.|
|Cellular Location||Cytoplasm. Nucleus|
|Tissue Location||Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. Expressed in monocytes and lymphocytes but not in granulocytes|
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Provided below are standard protocols that you may find useful for product applications.
CK1e is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. This protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. It has been shown to phosphorylate period, a circadian rhythm protein.
Hino, S., et al., J. Biol. Chem. 278(16):14066-14073 (2003). Eide, E.J., et al., J. Biol. Chem. 277(19):17248-17254 (2002). Keesler, G.A., et al., Neuroreport 11(5):951-955 (2000). Cegielska, A., et al., J. Biol. Chem. 273(3):1357-1364 (1998). Kloss, B., et al., Cell 94(1):97-107 (1998).
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