|Other Names||Homeobox protein HMX3, Homeobox protein H6 family member 3, Homeobox protein Nkx-51, Hmx3, Nkx-51, Nkx5-1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7424b was selected from the C-term region of human Mouse Hmx3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. Binds to the 5'-CAAGTG-3' core sequence. Controls semicircular canal formation in the inner ear. Also required for hypothalamic/pituitary axis of the CNS.|
|Tissue Location||Expressed in the developing CNS, including a specific expression in vestibular structures throughout inner ear development.|
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Provided below are standard protocols that you may find useful for product applications.
Hmx3 is a transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. This protein binds to the 5'-CAAGTG-3' core sequence. It controls semicircular canal formation in the inner ear and is also required for hypothalamic/pituitary axis of the CNS.
Mennerich D., Hoffmann S.,Biol. Chem. 380:1041-1048(1999) Rinkwitz-Brandt S., Justus M.,Mech. Dev. 52:371-381(1995) Rinkwitz-Brandt S., Arnold H.H., Bober E.Hear. Res. 99:129-138(1996)Amendt B.A., Sutherland L.B.,J. Biol. Chem. 274:11635-11642(1999)
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