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HIBCH Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q6NVY1 |
|---|---|
| Other Accession | NP_055177 |
| Clone Names | 81028059 |
| Gene ID | 26275 |
|---|---|
| Other Names | 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial, 3-hydroxyisobutyryl-coenzyme A hydrolase, HIB-CoA hydrolase, HIBYL-CoA-H, HIBCH |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | HIBCH |
|---|---|
| Function | Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA. |
| Cellular Location | Mitochondrion. |
| Tissue Location | Highly expressed in liver and kidney, also detected in heart, muscle and brain (at protein level). Not detected in lung |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Beta-hydroxyisobutyryl-CoA hydrolase (EC 3.1.2.4) isresponsible for the specific hydrolysis of HIBYL-CoA, a valinecatabolite, as well as the hydrolysis of beta-hydroxypropionyl-CoA,an intermediate in a minor pathway of propionatemetabolism.
References
Wu, C., et al. Proteomics 7(11):1775-1785(2007)Loupatty, F.J., et al. Am. J. Hum. Genet. 80(1):195-199(2007)Ishigure, K., et al. Clin. Chim. Acta 312 (1-2), 115-121 (2001) Hawes, J.W., et al. J. Biol. Chem. 271(42):26430-26434(1996)Shimomura, Y., et al. J. Biol. Chem. 269(19):14248-14253(1994)
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