|Other Names||Multidrug resistance-associated protein 4, ATP-binding cassette sub-family C member 4, MRP/cMOAT-related ABC transporter, Multi-specific organic anion transporter B, MOAT-B, ABCC4, MRP4|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7436b was selected from the C-term region of human ABCC4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May be an organic anion pump relevant to cellular detoxification.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Widely expressed, with particularly high levels in prostate, but is barely detectable in liver|
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Provided below are standard protocols that you may find useful for product applications.
ABCC4 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC proteins are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in cellular detoxification as a pump for its substrate, organic anions.
Lee K., Belinsky M.G., Bell D.W.Cancer Res. 58:2741-2747(1998)Adachi M., Sampath J., Lan L.B.J. Biol. Chem. 277:38998-39004(2002)Kool M., de Haas M., Scheffer G.L.Cancer Res. 57:3537-3547(1997) Janke D., Mehralivand S., Strand D.Hum. Mutat. 29:659-669(2008)
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