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ABCC4 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession O15439
Clone Names 80325104
Peptide ID 80325104
Additional Information
Gene ID 10257
Other Names Multidrug resistance-associated protein 4, ATP-binding cassette sub-family C member 4, MRP/cMOAT-related ABC transporter, Multi-specific organic anion transporter B, MOAT-B, ABCC4, MRP4
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7436b was selected from the C-term region of human ABCC4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ABCC4
Synonyms MRP4
Function May be an organic anion pump relevant to cellular detoxification.
Cellular Location Membrane; Multi-pass membrane protein.
Tissue Location Widely expressed, with particularly high levels in prostate, but is barely detectable in liver
Research Areas
Citations (0)

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Background

ABCC4 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC proteins are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in cellular detoxification as a pump for its substrate, organic anions.

References

Lee K., Belinsky M.G., Bell D.W.Cancer Res. 58:2741-2747(1998)Adachi M., Sampath J., Lan L.B.J. Biol. Chem. 277:38998-39004(2002)Kool M., de Haas M., Scheffer G.L.Cancer Res. 57:3537-3547(1997) Janke D., Mehralivand S., Strand D.Hum. Mutat. 29:659-669(2008)

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$ 80.00
Cat# BP7436b
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