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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   ADAMTS4 Antibody (C-term) Blocking Peptide   

ADAMTS4 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O75173
Clone Names 80325132
Peptide ID 80325132
Additional Information
Gene ID 9507
Other Names A disintegrin and metalloproteinase with thrombospondin motifs 4, ADAM-TS 4, ADAM-TS4, ADAMTS-4, ADMP-1, Aggrecanase-1, ADAMTS4, KIAA0688
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7439b was selected from the C-term region of human ADAMTS4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms KIAA0688
Function Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.
Cellular Location Secreted, extracellular space, extracellular matrix
Tissue Location Expressed in brain, lung and heart. Expressed at very low level in placenta and skeletal muscles. Isoform 2 is detected in osteoarthritic synovium
Research Areas
Citations (0)

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ADAMTS4 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma.


Tortorella M.D., Burn T.C.Science 284:1664-1666(1999) Tortorella M.D., Pratta M.A., Liu R.-Q.J. Biol. Chem. 275:25791-25797(2000)

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$ 80.00
Cat# BP7439b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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