|Other Names||Amine oxidase [flavin-containing] A, Monoamine oxidase type A, MAO-A, MAOA|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7463a was selected from the N-term region of human MAOA. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.|
|Cellular Location||Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side|
|Tissue Location||Heart, liver, duodenum, blood vessels and kidney|
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Provided below are standard protocols that you may find useful for product applications.
MAOA, monoamine oxidase A, an enzyme that degrades amine neurotransmitters, such as dopamine, norepinephrine, and serotonin. The protein localizes to the mitochondrial outer membrane. This protein is adjacent to a related gene on the opposite strand of chromosome X. Mutation in MAOA gene results in monoamine oxidase deficiency, or Brunner syndrome.
Zhu Q.S., Grimsby J.S.J. Neurosci. 12:4437-4446(1992)De Colibus L., Li M.Proc. Natl. Acad. Sci. U.S.A. 102:12684-12689(2005)
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