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GPT Antibody (N-term P101) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P24298 |
|---|---|
| Clone Names | 81020137 |
| Gene ID | 2875 |
|---|---|
| Other Names | Alanine aminotransferase 1, ALT1, Glutamate pyruvate transaminase 1, GPT 1, Glutamic--alanine transaminase 1, Glutamic--pyruvic transaminase 1, GPT, AAT1, GPT1 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP7468a was selected from the N-term region of human GPT. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | GPT |
|---|---|
| Synonyms | AAT1, GPT1 |
| Function | Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles (By similarity). |
| Cellular Location | Cytoplasm. |
| Tissue Location | Liver, kidney, heart, and skeletal muscles. Expressed at moderate levels in the adipose tissue |
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Provided below are standard protocols that you may find useful for product applications.
Background
GPT(Glutamate-pyruvate transaminase), also known as alanine aminotransferase, catalyzes the reversible conversion of L-alanine and alpha-ketoglutarate to L-glutamate and pyruvate. This protein has 2 distinct molecular and genetic forms: one cytoplasmic (soluble) (GPT1) and one mitochondrial (GPT2). See ALTQTL1 and ALTQTL2 for information on quantitative trait loci influencing the plasma level of alanine aminotransferase.
References
Yang R.-Z., Blaileanu G.Genomics 79:445-450(2002)Ishiguro M., Takio K.Biochemistry 30:10451-10457(1991)
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