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IGHM Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P01871
Clone Names 80917007
Peptide ID 80917007
Additional Information
Other Names Ig mu chain C region, IGHM
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7470a was selected from the N-term region of human IGHM. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Function IgM antibodies play an important role in primary defense mechanisms. They have been shown to be involved in early recognition of external invaders like bacteria and viruses, cellular waste and modified self, as well as in recognition and elimination of precancerous and cancerous lesions. The membrane- bound form is found in the majority of normal B-cells alongside with IgD. Membrane-bound IgM induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. It may cause death of cells by apoptosis. It is also found in soluble form, which represents about 30% of the total serum immunoglobulins where it is found almost exclusively as a homopentamer. After the antigen binds to the B-cell receptor, the secreted form is secreted in large amounts.
Cellular Location Isoform 1: Secreted. Note=During differentiation, B-lymphocytes switch from expression of membrane- bound IgM to secretion of IgM
Research Areas
Citations (0)

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Dorai H., Gillies S.D.Nucleic Acids Res. 17:6412-6412(1989)Rabbitts T.H.Nucleic Acids Res. 9:4509-4524(1981)Watanabe S.Hoppe-Seyler's Z. Physiol. Chem. 354:1505-1509(1973)

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$ 80.00
Cat# BP7470a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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Ordering Information

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