|Other Names||Ig mu chain C region, IGHM|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7470a was selected from the N-term region of human IGHM. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||IgM antibodies play an important role in primary defense mechanisms. They have been shown to be involved in early recognition of external invaders like bacteria and viruses, cellular waste and modified self, as well as in recognition and elimination of precancerous and cancerous lesions. The membrane- bound form is found in the majority of normal B-cells alongside with IgD. Membrane-bound IgM induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. It may cause death of cells by apoptosis. It is also found in soluble form, which represents about 30% of the total serum immunoglobulins where it is found almost exclusively as a homopentamer. After the antigen binds to the B-cell receptor, the secreted form is secreted in large amounts.|
|Cellular Location||Isoform 1: Secreted. Note=During differentiation, B-lymphocytes switch from expression of membrane- bound IgM to secretion of IgM|
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Provided below are standard protocols that you may find useful for product applications.
Dorai H., Gillies S.D.Nucleic Acids Res. 17:6412-6412(1989)Rabbitts T.H.Nucleic Acids Res. 9:4509-4524(1981)Watanabe S.Hoppe-Seyler's Z. Physiol. Chem. 354:1505-1509(1973)
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