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IGHM Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P01871
Peptide ID 80917008
Additional Information
Other Names Ig mu chain C region, IGHM
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name IGHM
Function IgM antibodies play an important role in primary defense mechanisms. They have been shown to be involved in early recognition of external invaders like bacteria and viruses, cellular waste and modified self, as well as in recognition and elimination of precancerous and cancerous lesions. The membrane- bound form is found in the majority of normal B-cells alongside with IgD. Membrane-bound IgM induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. It may cause death of cells by apoptosis. It is also found in soluble form, which represents about 30% of the total serum immunoglobulins where it is found almost exclusively as a homopentamer. After the antigen binds to the B-cell receptor, the secreted form is secreted in large amounts.
Cellular Location Isoform 1: Secreted. Note=During differentiation, B-lymphocytes switch from expression of membrane- bound IgM to secretion of IgM
Research Areas
Citations (0)

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References

Dorai H., Gillies S.D.Nucleic Acids Res. 17:6412-6412(1989)Rabbitts T.H.Nucleic Acids Res. 9:4509-4524(1981)Watanabe S.Hoppe-Seyler's Z. Physiol. Chem. 354:1505-1509(1973)

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$ 80.00
Cat# BP7470b
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