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OAZ1 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P54368
Clone Names 80917102
Peptide ID 80917102
Additional Information
Gene ID 4946
Other Names Ornithine decarboxylase antizyme 1, ODC-Az, OAZ1, OAZ
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7477a was selected from the N-term region of human OAZ1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name OAZ1
Synonyms OAZ
Function Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake by binding to and targeting ODC1 for degradation (PubMed:17900240). Stabilizes AZIN2 by interfering with its ubiquitination. Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol.
Research Areas
Citations (0)

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OAZ1 catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis. This protein play a role in the regulation of polyamine synthesis by binding to and inhibiting ornithine decarboxylase. The protein expression is auto-regulated by polyamine-enhanced translational frameshifting.


Grimwood J., Gordon L.A.Nature 428:529-535(2004)Hayashi T., Matsufuji S.Gene 203:131-139(1997)Tewari D.S., Qian Y.Biochim. Biophys. Acta 1209:293-295(1994)

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$ 80.00
Cat# BP7477a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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