|Other Names||Dermatopontin, Tyrosine-rich acidic matrix protein, TRAMP, DPT|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7485c was selected from the Center region of human DPT. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation (By similarity).|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Expressed in fibroblasts, heart, skeletal muscle, brain and pancreas. Expressed at an intermediate level in lung and kidney, and at a low level in liver and placenta Expressed at a lower level in fibroblasts from hypertrophic scar lesional skin and in fibroblasts from patients with systemic sclerosis than in normal skin fibroblasts|
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Provided below are standard protocols that you may find useful for product applications.
DPT is an extracellular matrix protein with possible functions in cell-matrix interactions and matrix assembly. This protein is found in various tissues and many of its tyrosine residues are sulphated. The protein is postulated to modify the behavior of TGF-beta through interaction with decorin.
Cheung,C.L., Chan,B.Y. Hum. Mol. Genet. 18 (4), 679-687 (2009)Pochampally,R.R., Ylostalo,J. J. Bone Miner. Res. 22 (9), 1338-1349 (2007)Lunetta,K.L., D'Agostino,R.B. Sr. BMC Med. Genet. 8 SUPPL 1, S13 (2007)
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