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ALAS1 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P13196 |
|---|---|
| Clone Names | 80924051 |
| Gene ID | 211 |
|---|---|
| Other Names | 5-aminolevulinate synthase, nonspecific, mitochondrial, ALAS-H, 5-aminolevulinic acid synthase 1, Delta-ALA synthase 1, Delta-aminolevulinate synthase 1, ALAS1, ALAS3, ALASH |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP7486b was selected from the C-term region of human ALAS1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ALAS1 |
|---|---|
| Synonyms | ALAS3, ALASH |
| Function | Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products. |
| Cellular Location | Mitochondrion inner membrane {ECO:0000250|UniProtKB:P22557}; Peripheral membrane protein {ECO:0000250|UniProtKB:P22557}. Note=Localizes to the matrix side of the mitochondrion inner membrane. {ECO:0000250|UniProtKB:P22557} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
ALAS1 catalyzes the condensation of glycine with succinyl-CoA to form delta-aminolevulinic acid. This protein is the first and rate-limiting enzyme in the mammalian heme biosynthetic pathway. There are 2 tissue-specific isozymes: a housekeeping enzyme encoded by the ALAS1 gene and an erythroid tissue-specific enzyme encoded by ALAS2.
References
Zheng,J., Shan,Y. Mol. Cell. Biochem. 319 (1-2), 153-161 (2008)May,B.K., Bhasker,C.R. Mol. Biol. Med. 7 (5), 405-421 (1990)Tsang,H.T., Connell,J.W. Genomics 88 (3), 333-346 (2006)
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