|Other Names||5-aminolevulinate synthase, nonspecific, mitochondrial, ALAS-H, 5-aminolevulinic acid synthase 1, Delta-ALA synthase 1, Delta-aminolevulinate synthase 1, ALAS1, ALAS3, ALASH|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7486b was selected from the C-term region of human ALAS1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Mitochondrion matrix.|
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Provided below are standard protocols that you may find useful for product applications.
ALAS1 catalyzes the condensation of glycine with succinyl-CoA to form delta-aminolevulinic acid. This protein is the first and rate-limiting enzyme in the mammalian heme biosynthetic pathway. There are 2 tissue-specific isozymes: a housekeeping enzyme encoded by the ALAS1 gene and an erythroid tissue-specific enzyme encoded by ALAS2.
Zheng,J., Shan,Y. Mol. Cell. Biochem. 319 (1-2), 153-161 (2008)May,B.K., Bhasker,C.R. Mol. Biol. Med. 7 (5), 405-421 (1990)Tsang,H.T., Connell,J.W. Genomics 88 (3), 333-346 (2006)
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