|Other Names||F-actin-capping protein subunit alpha-1, CapZ alpha-1, CAPZA1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7488a was selected from the N-term region of human CAPZA1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.|
|Cellular Location||Cytoplasm, cytoskeleton.|
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Provided below are standard protocols that you may find useful for product applications.
CAPZA1 is a member of the F-actin capping protein alpha subunit family. The protein regulates growth of the actin filament by capping the barbed end of growing actin filaments.
Maun,N.A., Speicher,D.W. Biochemistry 35 (11), 3518-3524 (1996)Barron-Casella,E.A., Torres,M.A. J. Biol. Chem. 270 (37), 21472-21479 (1995)Canton,D.A., Olsten,M.E. J. Biol. Chem. 281 (47), 36347-36359 (2006)
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