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TCP1 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P17987
Clone Names 80924237
Additional Information
Gene ID 6950
Other Names T-complex protein 1 subunit alpha, TCP-1-alpha, CCT-alpha, TCP1, CCT1, CCTA
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7490a was selected from the N-term region of human TCP1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TCP1
Synonyms CCT1, CCTA
Function Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable).
Cellular Location Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Research Areas
Citations (0)
citation

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Background

TCP1 is member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin.

References

Villebeck,L., Moparthi,S.B. Biochemistry 46 (44), 12639-12647 (2007)Tang,W., Shi,Y., Feng,G.J. Neural Transm. 113 (10), 1537-1543 (2006)Yaffe,M.B., Farr,G.W. Nature 358 (6383), 245-248 (1992)

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$ 277.78
Cat# BP7490a
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Availability: 2 weeks
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