|Other Names||Pleckstrin homology domain-containing family A member 3, PH domain-containing family A member 3, Phosphatidylinositol-four-phosphate adapter protein 1, FAPP-1, Phosphoinositol 4-phosphate adapter protein 1, PLEKHA3, FAPP1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7499b was selected from the C-term region of human FAPP1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in Golgi to cell surface membrane traffic. Induces membrane tubulation. Binds preferentially to phosphatidylinositol 4-phosphate (PtdIns4P).|
|Cellular Location||Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
FAPP1 binds specifically to phosphatidylinositol-4-phosphate (PtdIns4P), but not to other phosphoinositides.
Godi,A., Di Campli,A. Nat. Cell Biol. 6 (5), 393-404 (2004)Dowler,S., Currie,R.A. Biochem. J. 351 (PT 1), 19-31 (2000)
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