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ERK4 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P31152
Clone Names 2030412
Peptide ID 2030412
Additional Information
Gene ID 5596
Other Names Mitogen-activated protein kinase 4, MAP kinase 4, MAPK 4, Extracellular signal-regulated kinase 4, ERK-4, MAP kinase isoform p63, p63-MAPK, MAPK4, ERK4, PRKM4
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7503a was selected from the C-term region of human ERK4 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MAPK4
Synonyms ERK4, PRKM4
Function Atypical MAPK protein. Phosphorylates microtubule- associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle (By similarity).
Cellular Location Cytoplasm. Nucleus. Note=Translocates to the cytoplasm following interaction with MAPKAPK5.
Tissue Location High expression in heart and brain.
Research Areas
Citations (0)

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Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The CMGC group consists of 60 kinases including the cyclin-dependent kinase (CDK) and close relatives family, the MAP kinase (ERK) family, the glycogen synthase kinase 3 (GSK3) family, and the Cdc2-like kinase (CLK) family.


Robinson, M.J., et al., Curr. Opin. Cell Biol. 9(2):180-186 (1997).Davis, R.J., Mol. Reprod. Dev. 42(4):459-467 (1995).Seger, R., et al., FASEB J. 9(9):726-735 (1995).Li, L., et al., Oncogene 9(2):647-649 (1994).Zhu, A.X., et al., Mol. Cell. Biol. 14(12):8202-8211 (1994).

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$ 80.00
Cat# BP7503a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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