|Other Names||Cyclin-dependent kinase 13, CDC2-related protein kinase 5, Cell division cycle 2-like protein kinase 5, Cell division protein kinase 13, hCDK13, Cholinesterase-related cell division controller, CDK13, CDC2L, CDC2L5, CHED, KIAA1791|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7514a was selected from the N-term region of human CDC2L5 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||CDC2L, CDC2L5, CHED, KIAA1791|
|Function||Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys- 51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef.|
|Cellular Location||Nucleus speckle|
|Tissue Location||Expressed in fetal brain, liver, muscle and in adult brain. Also expressed in neuroblastoma and glioblastoma tumors|
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Provided below are standard protocols that you may find useful for product applications.
CDC2L5, a member of the CDC2/CDKX subfamily of Ser/Thr protein kinases, may be a controller of the mitotic cell cycle. This protein is involved in the blood cell development. Expression is found in fetal brain, liver, muscle and in adult brain, and also in neuroblastoma and glioblastoma tumors.
Lapidot-Lifson, Y., et al., Proc. Natl. Acad. Sci. U.S.A. 89(2):579-583 (1992).
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