|Other Names||Cell division cycle 7-related protein kinase, CDC7-related kinase, HsCdc7, huCdc7, CDC7, CDC7L1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7515a was selected from the N-term region of human CDC7L1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication. Can phosphorylates MCM2 and MCM3.|
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Provided below are standard protocols that you may find useful for product applications.
CDC7L1 is predominantly localized in the nucleus and is a cell division cycle protein with kinase activity. Although expression levels of the protein appear to be constant throughout the cell cycle, the protein kinase activity appears to increase during S phase. It has been suggested that the protein is essential for initiation of DNA replication and that it plays a role in regulating cell cycle progression. Overexpression of this gene product may be associated with neoplastic transformation for some tumors.
Montagnoli, A., et al., EMBO J. 21(12):3171-3181 (2002).Hess, G.F., et al., Gene 211(1):133-140 (1998).Jiang, W., et al., Proc. Natl. Acad. Sci. U.S.A. 94(26):14320-14325 (1997).Sato, N., et al., EMBO J. 16(14):4340-4351 (1997).
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