|Other Names||Cyclin-dependent kinase 10, Cell division protein kinase 10, Serine/threonine-protein kinase PISSLRE, CDK10|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7516a was selected from the N-term region of human CDK10 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells).|
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Provided below are standard protocols that you may find useful for product applications.
CDK10 belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation. Its function is limited to cell cycle G2-M phase.
Crawford, J., et al., Genomics 56(1):90-97 (1999).Brambilla, R., et al., Oncogene 9(10):3037-3041 (1994).Grana, X., et al., Oncogene 9(7):2097-2103 (1994).Morgan, D. O. Annu. Rev. Cell Dev. Biol. 13, 261 (1997)Sherr, C. Science 274:1672 (1996)Kamb A. TIG 11:136 (1995)Zhang, H. et al, Cell 82, 915 (1995)Parge, HE. et al., Science 262, 387 (1993)Hershko, A. et al., Ann. Rev. Biochem. 61, 761 (1992)Peters, JM. Curr. Biol. 10, 759 (1998)Skowyra, D. etal., Cell 91, 209 (1997)Ganoth D. et al., Nature Cell Biol. 3, 321-324 (2001)
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