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CDK3 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q00526
Clone Names 3010209
Peptide ID 3010209
Additional Information
Gene ID 1018
Other Names Cyclin-dependent kinase 3, Cell division protein kinase 3, CDK3, CDKN3
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7519b was selected from the C-term region of human CDK3 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CDK3
Synonyms CDKN3
Function Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0- G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1- independent manner.
Tissue Location Expressed in cancer cell lines and glioblastoma tissue.
Research Areas
Citations (0)

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Background

This gene encodes a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase, in part by activating members of the E2F family of transcription factors. The protein also associates with cyclin C and phosphorylates the retinoblastoma 1 protein to promote exit from G0.

References

Bullrich, F., et al., Cancer Res. 55(6):1199-1205 (1995).Meyerson, M., et al., EMBO J. 11(8):2909-2917 (1992).

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$ 80.00
Cat# BP7519b
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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