CDK3 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q00526 |
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Clone Names | 3010209 |
Gene ID | 1018 |
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Other Names | Cyclin-dependent kinase 3, Cell division protein kinase 3, CDK3, CDKN3 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP7519b was selected from the C-term region of human CDK3 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | CDK3 |
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Synonyms | CDKN3 |
Function | Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner. |
Tissue Location | Expressed in cancer cell lines and glioblastoma tissue. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase, in part by activating members of the E2F family of transcription factors. The protein also associates with cyclin C and phosphorylates the retinoblastoma 1 protein to promote exit from G0.
References
Bullrich, F., et al., Cancer Res. 55(6):1199-1205 (1995).Meyerson, M., et al., EMBO J. 11(8):2909-2917 (1992).
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