|Other Names||Cyclin-dependent kinase inhibitor 3, CDK2-associated dual-specificity phosphatase, Cyclin-dependent kinase interactor 1, Cyclin-dependent kinase-interacting protein 2, Kinase-associated phosphatase, CDKN3, CDI1, CIP2, KAP|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7528b was selected from the C-term region of human CDKN3 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||CDI1, CIP2, KAP|
|Function||May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner.|
|Cellular Location||Cytoplasm, perinuclear region|
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CDKN3 belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. The gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers.
Yeh, C.T., et al., Biochem. Biophys. Res. Commun. 305(2):311-314 (2003).Yeh, C.T., et al., Cancer Res. 60(17):4697-4700 (2000).Lee, S.W., et al., Mol. Cell. Biol. 20(5):1723-1732 (2000).Poon, R.Y., et al., Science 270(5233):90-93 (1995).Hannon, G.J., et al., Proc. Natl. Acad. Sci. U.S.A. 91(5):1731-1735 (1994).
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