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CLK4 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9HAZ1
Clone Names 3011306
Peptide ID 3011306
Additional Information
Gene ID 57396
Other Names Dual specificity protein kinase CLK4, CDC-like kinase 4, CLK4
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7532a was selected from the N-term region of human CLK4 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CLK4
Function Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3. Required for the regulation of alternative splicing of MAPT/TAU. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.
Cellular Location Nucleus.
Tissue Location Expressed in liver, kidney, heart, muscle, brain and endothelial cells.
Research Areas
Citations (0)

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CLK4 belongs to the CDC2-like protein kinase (CLK) family. This protein kinase can interact with and phosphorylate the serine- and arginine-rich (SR) proteins, which are known to play an important role in the formation of spliceosomes, and thus may be involved in the regulation of alternative splicing. Studies in the Israeli sand rat Psammomys obesus suggested that the ubiquitin-like 5 (UBL5/BEACON), a highly conserved ubiquitin-like protein, may interact with and regulate the activity of this kinase.


McNally, T., et al., Protein Sci. 12(7):1562-1566 (2003).Katsu, R., et al., J. Biol. Chem. 277(46):44220-44228 (2002).Schultz, J., et al., Genomics 71(3):368-370 (2001).

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$ 80.00
Cat# BP7532a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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