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DYRK3 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O43781
Clone Names 2121812
Peptide ID 2121812
Additional Information
Gene ID 8444
Other Names Dual specificity tyrosine-phosphorylation-regulated kinase 3, Regulatory erythroid kinase, REDK, DYRK3
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7535a was selected from the N-term region of human DYRK3 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name DYRK3
Function Negative regulator of EPO-dependent erythropoiesis, may place an upper limit on red cell production during stress erythropoiesis. Inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells. May act by regulating CREB/CRE signaling.
Cellular Location Nucleus.
Tissue Location Isoform 1 and isoform 2 are highly expressed in testis and in hematopoietic tissue such as fetal liver, and bone marrow. Isoform 2 is the predominant form in testis. Isoform 1 is the predominant form in fetal liver and bone marrow. Isoform 1 and isoform 2 are present at low levels in heart, pancreas, lymph node, and thymus.
Research Areas
Citations (0)

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This gene product belongs to the DYRK family of dual-specificity protein kinases that catalyze autophosphorylation on serine/threonine and tyrosine residues. The members of this family share structural similarity, however, differ in their substrate specificity, suggesting their involvement in different cellular functions. The encoded protein has been shown to autophosphorylate on tyrosine residue and catalyze phosphorylation of histones H3 and H2B in vitro. Alternatively spliced transcript variants encoding different isoforms have been identified.


Becker, W., et al., J. Biol. Chem. 273(40):25893-25902 (1998).Xia, J., et al., Zhonghua Yi Xue Yi Chuan Xue Za Zhi 15(6):327-332 (1998).

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$ 80.00
Cat# BP7535a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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